{"id":5449,"date":"2015-04-10T11:35:23","date_gmt":"2015-04-10T09:35:23","guid":{"rendered":"https:\/\/www.gkm-therapieforschung.de\/publications\/"},"modified":"2026-02-24T13:58:44","modified_gmt":"2026-02-24T12:58:44","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.gkm-therapieforschung.de\/en\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Publications<\/h1><\/span>
<\/div><\/div><\/div>

Here you can find publications of GKM employees and projects that GKM has carried out or supported.<\/p>\n<\/div>

<\/div><\/div><\/div>

2025<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 <\/span><\/span>Jessner C, Russell REK , Greulich T, Lommatzsch M, Suppli Ulrik C, Pohl W, Plaza V , Bourdin A, Kupczyk M, Braido F , Piraino A, Scaffidi-Argentina U , Bogoevska V, Trinkmann F
\n<\/span>Real-World Effectiveness and Safety of Single Inhaler Triple Therapy with Beclometasone\/ Formoterol\/ Glycopyrronium in Moderate to Severe Asthma: TriMaximize Study<\/span>
\nhttps:\/\/doi.org\/10.2147\/JAA.S582286<\/a><\/span><\/span><\/span>
\n<\/span><\/p>\n<\/div>

\u2192 <\/span>Julia Hibbert, Korbinian Weigl, Kaja Tikk, Stefanie J Klug, Matthias Schwab, Svitlana Igel, Oliver M\u00fcller, Marcus Pichler, Enrico N DeToni, Alexander Philipp, Jutta Nagel, Renate Schmelz, Anna-Magdalena Brosch, Frank Kolligs, Michael Hoffmeister, Hermann Brenner<\/span>
\n<\/span>Actual and Perceived Risk of Colorectal Neoplasia in First-Degree Relatives of Patients with Colorectal Cancer<\/span>
\nhttps:\/\/doi.org\/10.14309\/ctg.0000000000000893<\/a><\/span><\/span>
\n<\/span><\/p>\n<\/div>

\u2192 <\/span>Peter Kardos, Justus de Zeeuw, Inga Trompetter, Simon Braun and Yuliya Ilieva<\/span>
\n<\/span>Efficacy and Safety of a Single Ivy Extract Versus Two Herbal Extract Combinations in Patients with Acute Bronchitis: A Multi-Center, Randomized, Open-Label Clinical Trial<\/span>
\nhttps:\/\/doi.org\/10.3390\/ph18050754<\/a><\/span><\/span>
\n<\/span><\/p>\n<\/div>

\u2192 Denis Poddubnyy, Joachim Sieper, Servet Akar, Santiago Mu\u00f1oz-Fern\u00e1ndez, Hildrun Haibel, Mikhail Protopopov, Elisabeth Altmaier, Fabiana Ganz, Robert D Inman<\/span>
\nAchieving inactive disease state in men and women with axial spondyloarthritis: results from a multi-country prospective observational study<\/span>
\nhttps:\/\/doi.org\/10.1093\/rheumatology\/keaf447<\/a><\/span>
\n<\/span><\/p>\n<\/div>

\u2192 Kai\u2011Michael\u00a0Beeh, Karl\u00a0Scheithe, Heike\u00a0Schmutzler, Saskia\u00a0Kr\u00fcger<\/span>
\nClinically Important Improvements and Disease Stability with Fluticasone Furoate\/Umeclidinium\/Vilanterol Once\u2011Daily Single\u2011Inhaler Triple Therapy in the ELLITHE Trial: A Post Hoc Responder Analysis<\/span>
\nhttps:\/\/doi.org\/10.1007\/s41030-025-00306-1<\/a>
\n<\/span><\/p>\n<\/div>

\u2192 Wolfgang A Schmidt, Marco Alibone, Paul Ludwig, Dominik Oberm\u00fcller, Franziska Karl, Stephanie Terner, Nils Venhoff\u00a0 \u00a0<\/span>
\nFrequency, diagnosis, and management of polymyalgia rheumatica in Germany\u2014database analysis of medical insurance data<\/span>
\nhttps:\/\/doi.org\/10.1093\/rheumatology\/keaf367<\/span><\/a><\/span><\/p>\n<\/div>

\u2192 Stephan Weidinger, Tobias Schadeck, Felix Jacobs, Ansgar Weyergraf, Dariusch Mortazawi, Tobias Hagemann, Fatima Abousamra, Thomas Mosch, Bjoern Fritz & Felix Lauffer \u00a0\u00a0<\/span>
\nEarly Achievement of High Treatment Targets in Moderate-to-Severe Atopic Dermatitis with Upadacitinib: Real-World Evidence from the Observational UP-TAINED Study<\/span>
\nhttps:\/\/doi.org\/10.1007\/s13555-025-01373-7<\/a><\/span><\/p>\n<\/div>

2024<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 S\u00fcdmeyer M, Pedrosa DJ, Siebecker F, Arlt C, Kopra JJ, Jost WH \u00a0<\/span>
\nUtilization of MANAGE-PD Tool in a Real-World Setting in Germany: A Cross-Sectional Study Brain Sci. 2024 Jun 24;14(7):630. doi: 10.3390\/brainsci14070630
\n<\/span>PMID: 39061371<\/span>
\n<\/span>https:\/\/doi.org\/10.3390\/brainsci14070630<\/a><\/span><\/p>\n<\/div>

→ Daniel Weiss, Georg Ebersbach, Jens Carsten M\u00f6ller, Johannes Schwarz, Carolin Arlt, Bj\u00f6rn Fritz, Sven-Christian Sensken, Karla Eggert<\/p>

Do we start too late? Insights from the real-world non-interventional BALANCE study on the present use of levodopa\/carbidopa intestinal gel in advanced Parkinson's disease in Germany and Switzerland
\r\nDOI:\u00a0<\/span>10.1016\/j.parkreldis.2022.08.018<\/a><\/span><\/p><\/span>

→ Matthias Augustin, Dominik Beier, Jennifer Branner, Dennis H\u00e4ckl, Regina Hampel, Thomas Kramps, Hjalmar Kurzen, Hannah Lintener, Nima Melzer, Malina M\u00fcller, Petra Staubach, Uwe Schwichtenberg, Christian Termeer, Alexander Zink, Petra Nathan, Marcus Maurer<\/p>

The socio-economic burden of H1-antihistamine-refractory chronic spontaneous urticaria in Germany,
\r\nFirst published: 11 May 2024 https:\/\/doi.org\/10.1111\/jdv.20071<\/a><\/p><\/span>

→ Poddubnyy, Denis; Sieper, Joachim; Akar, Servet; Mu\u00f1oz-Fern\u00e1ndez, Santiago; Haibel, Hildrun; Diekhoff, Torsten; Protopopov, Mikhail; Altmaier, Elisabeth; Ganz, Fabiana; Inman, Robert D<\/p>

Radiographic Progression in Sacroiliac Joints in Patients With Axial Spondyloarthritis: Results From a Five-Year International Observational Study.
\r\nACR Open Rheumatol 6(2):p 103\u201310, Feb 2024. doi: 10.1002\/acr2.11642
\r\nhttp:\/\/doi.org\/10.1002\/acr2.11642<\/a><\/p><\/span>

→ Kai-Michael Beeh, Karl Scheithe, Heike Schmutzler & Saskia Kr\u00fcger<\/p>

Real-World Effectiveness of Fluticasone Furoate\/Umeclidinium\/Vilanterol Once-Daily
\r\nSingle-Inhaler Triple Therapy for Symptomatic COPD: The ELLITHE Non-Interventional Trial,
\r\nInternational Journal of Chronic Obstructive Pulmonary Disease, , 205-216, DOI: 10.2147\/
\r\nCOPD.S427770
\r\nhttps:\/\/doi.org\/10.2147\/COPD.S427770<\/a><\/p><\/span>\n<\/div>

2023<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Bernhard J Steinhoff, Tobias Goldmann, Edgar Kockelmann, Yaroslav Winter\u00a0<\/span>
\nA prospective non-interventional study of PERampanel as only adjunctive treatment in patients with PRImary or SEcondarily generalized tonic\u2013clonic seizures: First interim analysis
\nFirst published: 28 November 2023
\nhttps:\/\/doi.org\/10.1002\/epi4.12869<\/a><\/p>\n<\/div>

\u2192 Laura Sofia Cardelli, Quentin Delbaere, Fran\u00e7ois Massin, Mathieu Granier, Gianni Casella, Gaetano Barbato, Valentin Dupasquier, Jean-Christophe Macia, Florence Leclercq, Jean-Luc Pasquie, Fran\u00e7ois Roubille<\/span>
\nWearable Cardioverter Defibrillator Shortens the Lengths of Stay in Patients with Left Ventricular Dysfunction after Myocardial Infarction: A Single-Centre Real-World Experience
\nFirst published: 25 July 2023,
\nhttps:\/\/doi.org\/10.3390\/jcm12154884<\/a><\/p>\n<\/div>

\u2192 S. Weidinger, T. Schadeck, D. Mortazawi, P. H\u00e4usler-Mehlhorn, C. Lupp, T. Mosch, B. Fritz, F. Lauffer<\/span>
\nFirst results from the observational up-tained study on effectiveness and disease control in patients with moderate to severe atopic dermatitis treated with
\nupadacitinib (Abstract LB1677)
\nhttps:\/\/isid2023.org\/wp-content\/uploads\/2023\/05\/ISID_LateBreaking-Abstracts_Final-050523.pdf<\/a><\/p>\n<\/div>

→ Harbi, Othman Al; Owayed, Salem; Qari, Yousif; Mosli, Mahmoud; Anwar, Ali; Masri, Alaa; Gouda, Mohamed; Alfadhli, Ahmed<\/p>

Correlation between physician- and patient-directed disease assessments in ulcerative colitis patients from Saudi Arabia and Kuwait: Data from ICONIC
\r\nSaudi Journal of Gastroenterology 29(6):p 381-387, Nov \u2013 Dec 2023\u00a0 DOI: 10.4103\/sjg.sjg_92_23
\r\nhttps:\/\/doi.org\/DOI:%2010.4103\/sjg.sjg_92_23<\/a><\/p><\/span>

→ Dr. Ramona Sch\u00fctz, Sabine Ditz<\/p>

Lay Summaries of Clinical Trial Results
\r\nPharm. Ind. 85, Nr. 9, 835\u2013841 (2023):
\r\nhttps:\/\/tinyurl.com\/ar8kk4vv<\/a> or our blog article<\/a> on this topic.<\/p><\/span>

→ Seem\u00fcller F, Schennach R, Musil R, Obermeier M, Adli M, Bauer M, Brieger P, Laux G, Gaebel W, Falkai P, Riedel M, M\u00f6ller HJ<\/p>

A factor analytic comparison of three commonly used depression scales (HAMD, MADRS, BDI) in a large sample of depressed inpatients.
\r\nBMC Psychiatry. 2023 Jul 28;23(1):548. doi: 10.1186\/s12888-023-05038-7. PMID: 37507656; PMCID: PMC10386606.
\r\nhttps:\/\/doi.org\/10.1186\/s12888-023-05038-7<\/a><\/p><\/span>

→ Sylke Schneider-Burrus, Stefanie Kalus, Bj\u00f6rn Fritz, Kerstin Wolk, Susana Gomis-Kleindienst, Robert Sabat<\/p>

The impact of hidradenitis suppurativa on professional life.
\r\nBr J Dermatol. 2023 Jan 23;188(1):122-130. doi: 10.1093\/bjd\/ljac027. PMID: 36689513.
\r\nhttps:\/\/doi.org\/10.1093\/bjd\/ljac027<\/a><\/p><\/span>

→ A. Heratizadeh, M. Mempel, R. von Kiedrowski, S. Hagl, T. Mosch, B. Fritz, T. Werfel<\/p>

Checklist identification of candidates for systemic therapy in adult patients with atopic dermatitis in Germany: A multicentre study (2023)
\r\nhttps:\/\/doi.org\/10.1111\/jdv.19465<\/a><\/p><\/span>\n<\/div>

2022<\/h2><\/span>
<\/div><\/div><\/div>

→ Lund, L. H., Zeymer, U., Clark, A. L., Barrios, V., Damy, T., Dro\u017cd\u017c, J., Fonseca, C., Kalus, S., Ferber, P. C., Koch, C., Maggioni, A. P., & ARIADNE investigators (2022)<\/p>

Association between sacubitril\/valsartan initiation and changes in left ventricular ejection fraction:
\r\nInsights from ARIADNE registry. International journal of cardiology, S0167-5273(22)01480-2. Advance online publication. https:\/\/doi.org\/10.1016\/j.ijcard.2022.10.012<\/a><\/p><\/span>

→ Maggioni, A. P., Clark, A. L., Barrios, V., Damy, T., Drozdz, J., Fonseca, C., Lund, L. H., Kalus, S., Ferber, P. C., Hussain, R. I., Koch, C., Zeymer, U., & ARIADNE investigators (2022)<\/p>

Outcomes with sacubitril\/valsartan in outpatients with heart failure and reduced ejection fraction:
\r\nThe ARIADNE registry. ESC heart failure, 10.1002\/ehf2.14014. Advance online publication. https:\/\/doi.org\/10.1002\/ehf2.14014<\/a><\/p><\/span>

→ Zeymer, U., Clark, A. L., Barrios, V., Damy, T., Dro\u017cd\u017c, J., Fonseca, C., Lund, L. H., Kalus, S., Ferber, P. C., Hussain, R. I., Koch, C., & Maggioni, A. P. (2022)<\/p>

Utilization of sacubitril\/valsartan in patients with heart failure with reduced ejection fraction: real-world data from the ARIADNE registry. European heart journal.
\r\nQuality of care & clinical outcomes, 8(4), 469\u2013477. https:\/\/doi.org\/10.1093\/ehjqcco\/qcab019<\/a><\/p><\/span>

→ D. Poddubnyy, J. Sieper, S. Akar, S. Mu\u00f1oz-Fern\u00e1ndez, H. Haibel, T. Diekhoff, M. Protopopov, E. Altmaier, F. Ganz, R. Inman<\/p>

OP0149\u2005RADIOGRAPHIC PROGRESSION FROM NON-RADIOGRAPHIC TO RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM A 5-YEAR MULTICOUNTRY PROSPECTIVE OBSERVATIONAL STUDY
\r\nBMJ Annals of the Rheumatic Diseases - June 2022 - Volume 81 - Suppl 1
\r\nEULAR 2022 European Congress of Rheumatology, 1-4 June. Copenhagen<\/p><\/span>

→ Scholtz, A.W., Waldfahrer, F., Hampel, R. , Weisshaar, G.<\/p>

Efficacy and Safety of a Fixed-Dose Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg in the Treatment of Patients with Vestibular Vertigo: An Individual Patient Data Meta-Analysis of Randomised, Double-Blind, Controlled Clinical Trials.
\r\nClin Drug Investig (2022). https:\/\/doi.org\/10.1007\/s40261-022-01184-0<\/a><\/p><\/span>

→ Hans-Peter Tony, Eugen Feist, Peer Malte Aries, Silke Zinke, Klaus Kr\u00fcger, Jonas Ahlers, Inka Albrecht, Christian Barrionuevo, Stefanie Kalus, Harald Burkhardt<\/p>

Sarilumab reduces disease activity in rheumatoid arthritis patients with inadequate response to janus kinase inhibitors or tocilizumab in regular care in Germany,
\r\nRheumatology Advances in Practice, Volume 6, Issue 1, 2022, rkac002
\r\nhttps:\/\/doi.org\/10.1093\/rap\/rkac002<\/a><\/p><\/span>

→ Christian Gessner, Frederik Trinkmann, Sanaz Bahari Javan, Raimund H\u00f6velmann, Valentina Bogoevska, George Georges, Elena Nudo, and Carl-Peter Cri\u00e9e<\/p>

Effectiveness of Extrafine Single Inhaler Triple Therapy in Chronic Obstructive Pulmonary Disease (COPD) in Germany \u2013 The TriOptimize Study
\r\nInt J Chron Obstruct Pulmon Dis. 2022; 17: 3019\u20133031. Published online 2022 Dec 2. doi: 10.2147\/COPD.S382405
\r\nhttps:\/\/doi.org\/10.2147\/COPD.S382405<\/a><\/p><\/span>\n<\/div>

2021<\/h2><\/span>
<\/div><\/div><\/div>

→ Denis Poddubnyy, Joachim Sieper, Servet Akar, Santiago Mu\u00f1oz-Fern\u00e1ndez, Hildrun Haibel, Maja Hojnik, Fabiana Ganz, Robert D Inman<\/p>

Characteristics of Patients With Axial Spondyloarthritis by Geographic Regions: PROOF Multicountry
\r\nObservational Study Baseline Results
\r\nRheumatology (2021)
\r\nPublished online 13 December 2021, https:\/\/doi.org\/10.1093\/rheumatology\/keab901<\/a><\/p><\/span>

→ Jozsef Attila Szasz, Dragos Catalin Jianu, Mihaela Adriana Simu, Viorelia Adelina Constantin, Adriana Octaviana Dulamea, Koray Onuk, Diana Popescu, Mihai-Titus Vasile, Bogdan Ovidiu Popescu, Alfonso Fasano & Ovidiu Alexandru Bajenaru<\/p>

Characterizing Advanced Parkinson\u2019s Disease: Romanian Subanalysis from the OBSERVE-PD Study
\r\nParkinson\u2019s Disease (2021)
\r\nPublished online 25 January 2021, https:\/\/doi.org\/10.1155\/2021\/6635618<\/a><\/p><\/span>

→ Natalia Kirsten, Susana Gomis-Kleindienst, Sebastian Barbus, Matthias Augustin<\/p>

Treatment adjustment in commonly used biologics for the treatment of moderate to severe chronic plaque psoriasis: First results of the German retrospective chart review (TABU)
\r\nJournal der deutschen dermatologischen Gesellschaft, vol. 19, pp. 46-47, WILEY (2021)
\r\nPublished online 14 April, https:\/\/doi.org\/10.1111\/ddg.14459<\/a><\/p><\/span>

→ Sara Kaestner, Hans-Juergen Wolff, Rolf Braeuer, Peter Kaestner<\/p>

Immunoglobulin deficiencies in treated patients suffering from rheumatoid arthritis
\r\nRheumatology International (2021)
\r\nPublished online 29 April 2021: https:\/\/doi.org\/10.1007\/s00296-021-04871-x<\/a><\/p><\/span>\n<\/div>

2020<\/h2><\/span>
<\/div><\/div><\/div>

→ Anne-Marie Kanstrup Fiehn, Stephan Miehlke, Daniela Aust, Michael Vieth, Ole Bonderup, Fernando Fern\u00e1ndez-Ba\u00f1ares, Emese Mihaly, Juozas Kupcinskas, Ahmed Madisch, Lars Kristian Munck, Tanju Nacak, Ralf Mohrbacher, Ralph Mueller, Roland Greinwald, Andreas M\u00fcnch<\/p>

Distribution of histopathological features along the colonin microscopic colitis
\r\nEfficacy and tolerability of alirocumab in Austrian clinical practice \u2013 results of the non-interventional PEARL-AT study
\r\nInternational Journal of Colorectal Disease
\r\nPublished online 12 September 2020:https:\/\/doi.org\/10.1007\/s00384-020-03747-z<\/a><\/p><\/span>

→ Deborah R. Leitner, Hermann Toplak , Ludmilla Kedenko , Thomas Steinmaurer , Verena Gr\u00e4ff , Thomas Metzner , Elisabeth M. Schwaiger & Rudolf Prager<\/p>

Efficacy and tolerability of alirocumab in Austrian clinical practice \u2013 results of the non-interventional PEARL-AT study
\r\nPublished online 08 Jul 2020: https:\/\/doi.org\/10.1080\/03007995.2020.1786678<\/a> CrossMark Logo CrossMark <\/p><\/span>

→ Georgios Kokolakis, Kerstin Wolk, Sylke Schneider-Burrus, Stefanie Kalus, Sebastian Barbus, Susana Gomis-Kleindienst, Robert Sabat<\/p>

Delayed Diagnosis of Hidradenitis Suppurativa and Its Effect on Patients and Healthcare System
\r\nPublished online: July 1, 2020, DOI: 10.1159\/000508787<\/p><\/span>

→ Mich\u00e8le Augsburger, Gian-Marco Sarra & Pascal Imesch<\/p>

Treat and extend versus pro re nata regimens of ranibizumab and aflibercept in neovascular age-related macular degeneration: a comparative study
\r\nPublished online 29 June 2020: https:\/\/link.springer.com\/article\/10.1007\/s00417-019-04404-0<\/a><\/p><\/span>

→ Marc Schmalzing, MD, Frank Behrens, MD, Eva C. Schwaneck, MD, Michaela Koehm, MD, Gerd Greger, PhD, Holger Gnann, Dipl-State, Harald Burkhardt, MD, Hans-Peter Tony, MD<\/p>

Does concomitant methotrexate confer clinical bene\ufb01ts in patients treated with prior biologic therapy? Analysis of data from a noninterventional study of rheumatoid arthritis patients initiating treatment with adalimumab
\r\nPublished online: http:\/\/dx.doi.org\/10.1097\/MD.0000000000020201<\/a>
\r\nwww.md-journal.com<\/a><\/p><\/span>\n<\/div>

2019<\/h2><\/span>
<\/div><\/div><\/div>

→ Frank Behrens, Michaela Koehm, Eva C. Schwaneck, Marc Schmalzing, Holger Gnann, Gerd Greger, Hans-Peter Tony, Harald Burkhardt<\/p>

Use of a \u201ccritical difference\u201d statistical criterion improves the predictive utility of the Health Assessment Questionnaire-Disability Index score in patients with rheumatoid arthritis
\r\nBMC Part of Springer nature,
\r\nhttps:\/\/bmcrheumatol.biomedcentral.com\/articles\/10.1186\/s41927-019-0095-2<\/a>
\r\nPublished Online December 10, 2019; DOI: 10.1186\/s41927-019-0095-2<\/p><\/span>

→ Traussnigg S., Schattenberg J.M., Demir M., Wiegand J., Geier A., Teuber G., Hofmann W.P., Kremer A.E., Spreda F, Kluwe J., Petersen J., Boettler T., Rainer F., Halilbasic E., Greinwald R., Pr\u00f6ls M., Manns MP., Fickert P., Trauner M., on behalf of the Austrian\/German NAFLD-norUDCA study group<\/p>

Norursodeoxycholic acid versus placebo in the treatment of non-alcoholic fatty liver disease: a double-blind,
\r\nrandomised, placebo-controlled, phase 2 dose-finding trial
\r\nLancet Gastroenterol Hepatol 2019
\r\nPublished Online July 22, 2019; DOI: 10.1016\/S2468-1253(19)30184-0<\/p><\/span>

→ F. Behrens, M. Koehm, EC. Schwaneck, M. Schmalzing, BM. Wittig, H. Gnann, G. Greger, H-P. Tony & H Burkhardt (2019)<\/p>

Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis, Scandinavian Journal of Rheumatology,
\r\nfirst published online July 16.2019, DOI: 10.1080\/03009742.2019.1600717<\/p><\/span>

→ Augsburger M., Sarra G-M., Imesch P.<\/p>

Treat and extend versus pro re nata regimens of ranibizumab and aflibercept in neovascular age-related macular degeneration: a comparative study
\r\nGraefe\u2019s Archive for Clinical and Experimental Ophthalmology
\r\nFirst Online: 29 June 2019<\/p><\/span>

→ Zanos P., Keyworth H., Georgiou P., Hambsch B., Otte D. M., Kitchen I., Zimmer A., Bailey A.<\/p>

Chronic nicotine administration restores brain region specific upregulation of oxytocin receptor binding levels in a G72 mouse model of schizophrenia
\r\nEuropean Journal of Neuroscience , January 2019<\/p><\/span>\n<\/div>

2018<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Ancu\u021ba C., Petrariu L. A., Opri\u0219 Belinski D.
\nActivitatea fizic\u0103 la pacien\u0163ii cu poliartrit\u0103 reumatoid\u0103 trata\u0163i cu adalimumab \u00een practica clinic\u0103: Studiul PACE – rezultate locale Rom\u00e2nia
\nePoster Congresul Na\u0163ional de Reumatologie a XXV-a editie 12 Octombrie 2018 Poiana Brasov, Romania<\/p>\n

\u2192 Codreanu C , Ancu\u021ba C., Bojinc\u0103 M., Opri\u0219 Belinski D.
\nImpactul tratamentului cu adalimumab: rezultate clinice, utilizarea resurselor de asisten\u0163\u0103 medical\u0103 (inclusiv concedii medicale) la pacien\u021bii cu spondilita anchilozant\u0103 \u00een practica clinic\u0103: studiul IDEA -rezultate locale Rom\u00e2nia
\ne-Poster \/prezentare Congresul Na\u021bional De Reumatologie Edi\u021bia a XXV-a editie 12 Octombrie 2018 Poiana Brasov, Romania<\/p>\n

\u2192 Miehlke S., Aust D., Mihaly E., ArmerdingP., B\u00f6hm G., Bonderup O., Fern\u00e1ndez-Ba\u00f1ares F., Kupcinskas J., Munck L., RehbehnK.-U., Nacak T., Greinwald R., and M\u00fcnch A., on behalf of the BUG-1\/LMC Study Group
\nEfficacy and Safety of Budesonide, vs Mesalazine or Placebo, as Induction Therapy for Lymphocytic Colitis.
\nGastroenterology 2018 (available online 7 September 2018)<\/p>\n

\u2192 Dignass A., Schnabel R., Romatowski J., Pavlenko V., Dorofeyev A., Derova J., Jonaitis L., Dilger K., Nacak T. and Greinwald R.; the International SAT-25 Study Group
\nEfficacy and safety of a novel high-dose mesalazine tablet in mild to moderate active ulcerative colitis: a double-blind, multicentre, randomised trial
\nUnited European Gastroenterol J. 2018 Feb; 6(1):138-147<\/p>\n

\u2192 Behrens F., Koehm M., Schwaneck E. C., Schmalzing M., Gnann H., Greger G., Tony H.-P., Burkhardt H.
\nMinimal disease activity is a stable measure of therapeutic response in psoriatic arthritis patients receiving treatment with adalimumab. Rheumatology July 2018<\/p>\n<\/div>

2017<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Berges R., Schremmer D., Limberg R. Avanafil for the treatment of erectile dysfunction in practice. Non-interventional study AVANTI. MMW Fortschr Med. 2017 Jun;159(Suppl 5):16-21. doi: 10.1007\/s15006-017-9804-1, 2017<\/p>\n

\u2192 Patchev A., Lux H. SAE Reporting im Zeitalter der Digitalisierung. CRpro, Ausgabe 2, Mai 2017<\/p>\n

\u2192 R\u00f6thler A. Vigilanzsystem Experteninhalt, InnovationsLOTSE, www.medizintechnologie.de, 2017<\/p>\n

\u2192 Khobzey K., Liskova I., Szegedi A., Pavlovsky L., Lunder T., Kingo K., Miljkovi\u0107 J., P\u00e9\u010d J., Bohinc M., Hojnik M. Effectiveness of adalimumab in the treatment of scalp and nail affection in patients with moderate to severe plaque psoriasis in routine clinical practice. Acta Dermatovenerol Alp Pannonica Adriat. 26(1):11-14, 2017<\/p>\n

\u2192 Laux G., Barthel B., Hajak G., Lemke M., Volz H.-P. Pooled Analysis of Four Non-Interventional Studies: Effectiveness and Tolerability of the Antidepressant Agomelatine in Daily Practice. Adv Ther. 2017 Feb 18. doi: 10.1007\/s12325-017-0485-z. [Epub ahead of print], 2017<\/p>\n

\u2192 R\u00f6thler A. Post Market Surveillance (PMS) Experteninhalt, InnovationsLOTSE, www.medizintechnologie.de, 2017<\/p>\n

\u2192 R\u00f6thler A. Post Market Clinical Follow-up (PMCF) Experteninhalt, InnovationsLOTSE, www.medizintechnologie.de, 2017<\/p>\n<\/div>

2016<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Michetti P., Weinman J., Mrowietz U., Smolen J., Peyrin-Biroulet L., Louis E., Schremmer D., Tundia N., Nurwakagari P., Selenko-Gebauer N. Impact of Treatment-Related Beliefs on Medication Adherence in Immune-Mediated In\ufb02ammatory Diseases: Results of the Global ALIGN Study. Advances in Therapy, first published online: November 16, 2016, doi: 10.1007\/s12325-016-0441-3, 2016<\/p>\n

\u2192 Scharbatke E. C., Behrens F., Schmalzing M., Koehm M., Greger G., Gnann H., Burkhardt H., Tony H.-P. Association of Improvement in Pain With Therapeutic Response as Determined by Individual Improvement Criteria in Patients With Rheumatoid Arthritis. Arthritis Care Res (Hoboken); 68(11):1607-1615, 2016<\/p>\n

\u2192 Losch F.-P., Holtkamp M., McMurray R., Lendemans D., Kockelmann E. Antikonvulsive Zusatztherapie mit Eslicarbazepinacetat – Ergebnisse der EPOS-Studie bei Erwachsenen in Deutschland. Nervenarzt (2016), doi:10.1007\/s00115-016-0199-5, 2016<\/p>\n

\u2192 Patchev A., R\u00f6thler A., Schremmer D., Patchev S. Der \u201eNIS-Lotse\u201c: Antworten auf h\u00e4ufige Fragen bei der Planung einer nicht-interventionellen Studie. Pharmazeutische Medizin 02\/16, 2016<\/p>\n

\u2192 Behrens F., Koehm M., Thac D., Gnann H., Greger G., Wittig B.M., Burkhardt H. Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis. Rheumatology, first published online: June 21, 2016, doi: 10.1093\/rheumatology\/kew229, 2016<\/p>\n

\u2192 Ottiger C., Gygli N., Huber A.R., Fernandez-Tresguerres B., Pardo S., Petruschke T. Performance of a Blood Glucose Monitoring System in a Point-of-Care Setting. Journal of Diabetes Science and Technology. 2016 Mar 16. pii: 1932296816638854, 2016<\/p>\n

\u2192 Holtkamp M., McMurray R., Bagul M., Sousa R., Kockelmann E. Real-world data on eslicarbazepine acetate as add-on to antiepileptic monotherapy. Acta Neurol Scand; Article first published online: 24 FEB 2016, DOI: 10.1111\/ane.12574, 2016<\/p>\n<\/div>

2015<\/h2><\/span>
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\u2192 Scholtz A.W., Ilgner J., Loader B., Pritschow B.W., Weisshaar G. Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice. Wien Klin Wochenschr; 2015 Dec 11. [Epub ahead of print], 2015<\/p>\n

\u2192 Volz H.-P., Escafit-Sch\u00fclke M.-L. Effekte von Agomelatin bei depressiven Patienten im Praxisalltag – Ergebnisse der nicht interventionellen Studie VIVRE. Nervenheilkunde; 34: 809-817, 2015<\/p>\n

\u2192 Eisenhardt A., Schneider T., Scheithe K., Colling C., Heidenreich A., TRIPTOSIX-Studiengruppe. Lebensqualit\u00e4t\u202fvon\u202fPatienten\u202fmit\u202fProstatakarzinom\u202funter\u202fAndrogendeprivation\u202fmit\u202fGnRH-Analoga – Ergebnisse\u202fder\u202fnicht-interventionellen\u202fStudie\u202fTRIPTOSIX. Der Urologe; First online: 01 November 2015, doi:10.1007\/s00120-015-3989-7, 2015<\/p>\n

\u2192 Patchev A., Otto A., Engler C., Obermeier M. AMNOG: Was bei der Endpunktwahl f\u00fcr Zulassungsstudien zu ber\u00fccksichtigen ist. Pharmazeutische Medizin; 17(3): 134-139, 2015<\/p>\n

\u2192 Bedini J.L., Wallace J.F., Petruschke T., Pardo S. A Multicenter Performance Evaluation of a Blood Glucose Monitoring System in 21 Leading Hospitals in Spain. J Diabetes Sci Technol; pii: 1932296815598777 [Epub ahead of print] PubMed PMID: 26253142, 2015<\/p>\n

\u2192 Bedini J.L., Wallace J.F., Pardo S., Petruschke T. Performance Evaluation of Three Blood Glucose Monitoring Systems Using ISO 15197: 2013 Accuracy Criteria, Consensus and Surveillance Error Grid Analyses, and Insulin Dosing Error Modeling in a Hospital Setting. J Diabetes Sci Technol; pii: 1932296815609368 [Epub ahead of print] PubMed PMID: 26445813, 2015<\/p>\n

\u2192 Rothermel J., Scheithe K., Nazari N., Hauffa BP., Reniehr T. Adherence to Growth Hormone Treatment: Impact of Height, Age and Puberty. Poster presentation, European Society for Paediatric Endocrinology (ESPE) Congress 2015; Poster P3-936 Abstract 530; Barcelona, 1-3 October, 2015<\/p>\n

\u2192 Laux G., Barthel B., Hajak G., Lemke M., Volz H.P. Wirk- und Vertr\u00e4glichkeitsprofil des Antidepressivums Agomelatin in der t\u00e4glichen Praxis. Gepoolte Analyse von vier nicht-interventionellen Studien. Psychopharmakotherapie; 22:136-47, 2015<\/p>\n

\u2192 Engler C., Michelson G. Talkingeyes\u00ae – an ISO certified telemedical eye examination network as an effective tool for data collection in clinical research. Poster presentation, European Society of Ophthalmology (SOE) Congress 2015, Vienna, 6-9 June 2015.<\/p>\n

\u2192 Feuchtenberger M., Kleinert S., Scharbatke E.C., Gnann H., Behrens F., Wittig B.M., Greger G., Tony H.P. The impact of prior biologic therapy on adalimumab response in patients with rheumatoid arthritis. Clin Exp Rheumatol; 33(3):321-9, 2015.<\/p>\n

\u2192 Merseburger A.S., Scheithe K., Colling C. How patients prefer to learn that they have cancer: Results of a survey on patients\u2019 preference for communication in prostate cancer using the MPP-d (German version of the Measure of Patients\u2019 Preferences). J Clin Oncol 33 (suppl; abstr e20591), 2015.<\/p>\n

\u2192 Thaci D., Behrens F., Greger G., Burkhardt H., Gnann H., Schopf R., Wittig B.M. Association between Skin and Joint Involvement in Patients with Psoriatic Arthritis Treated with Adalimumab: Analysis of Data from a German Non-Interventional Study. Dermatology. 2015;230(3):213-21.<\/p>\n

\u2192 Ziegler R., Eichholz R., Schulz B. Use of a Combined Blood-Glucose- and beta-Ketone-Measuring Device Improves Glycemic Control in Insulin-Treated Patients with Diabetes: The Gold Plus Study. Journal of Diabetes Science and Technology; 1-5, 2015.<\/p>\n<\/div>

2014<\/h2><\/span>
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\u2192 Miehlke S., Madisch A., Kupcinskas L., Petrauskas D., Bohm G., Marks H.J., Neumeyer M., Nathan T., Fern\u00e1ndez-Banares F., Greinwald R., Mohrbacher R., Vieth M., Bonerdup O.K., and the BUC-60\/COC Study Group. Budesonide Is More Effective Than Mesalazine or Placebo in Short-term Treatment of Collagenous Colitis. Gastroentreology; 146(5):1222-1230, 2014.<\/p>\n

\u2192 Patchev A., Rost M., Engler C., Obermeier M., Hautmann C. The impact of German benefit assessment on endpoint selection in clinical research and drug development in Germany \u2013 lessons (to be) learned. Poster presentation, 16. Jahreskongress f\u00fcr klinische Pharmakologie, Cologne, October 9 – 10, 2014.<\/p>\n

\u2192 Rost M. An introduction to value dossiers for early benefit assessment in Germany \u2013 Part 1: Processes and players. Regulatory Rapporteur; Volume 11, Issue 11: 25-27, 2014.<\/p>\n

\u2192 Rost M. An introduction to value dossiers for early benefit assessment in Germany \u2013 Part 2: Demonstration of additional benefit. Regulatory Rapporteur; Volume 11, Issue 12: 29-32, 2014.<\/p>\n

\u2192 Witt C., Jehn M.L., Omid N., Hanisch M., Liebers U., Ehrlich R., Krohn I., Schremmer D. Multicenter study on COPD out-patient healthcare in Germany (ORCAS). Poster presentation, European Respiratory Society Annual Congress Munich, German, September 6\u201310, 2014.<\/p>\n<\/div>

2013<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Hefter H., Benecke R., Erbguth F., Jost W., Reichel G., Wissel J. An open-label cohort study of the improvement of quality of life and pain in de novo cervical dystonia patients after injections with 500 U botulinum toxin A (Dysport). BMJ Open; 3:e001853, doi:10.1136\/bmjopen-2012-001853, 2013.<\/p>\n

\u2192 Laux G., Huttner N. Agomelatin in der Depressionsbehandlung \u00fcber 12 Monate. Follow-up der VIVALDI-Studie. Psychopharmakotherapie; 20: 119-127, 2013.<\/p>\n

\u2192 Braun A., Gnann H., Saracbasi E., Grifka J., Kiltz U., Letschert K., Braun J. Optimizing the identification of patients with axial spondyloarthritis in primary care–the case for a two-step strategy combining the most relevant clinical items with HLA B27. Rheumatology (Oxford) 4;52(8):1418-24, 2013<\/p>\n

\u2192 Behrens F., Tony H.-P., Alten R., Kleinert S., Scharbatke E. C., K\u00f6hm M., Gnann H., Tams J., Greger G., Burkhardt H. Development and Validation of a New Disease Activity Score in 28 Joints\u2013Based Treatment Response Criterion for Rheumatoid Arthritis. Arthritis Care & Research Volume 65, Issue 10, pages 1608-1616, 2013<\/p>\n<\/div>

2012<\/h2><\/span>
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\u2192 Beer A.M., Fey S., Zimmer M., Teske W., Schremmer D., Wiebelitz K.R. Wirksamkeit und Sicherheit eines hom\u00f6opathischen Komplexpr\u00e4parates bei chronischen R\u00fcckenschmerzen. Doppelblinde, randomisierte, placebokontrollierte, klinische Studie. MMW (154. Jg): 48-57, 2012.<\/p>\n

\u2192 Nemes L., Pollmann H., Becker T. Interim data on long-term efficacy, safety and tolerability of a plasma-derived factor VIII concentrate in 109 patients with severe haemophilia A. Haemophilia; 1-7, 2012.<\/p>\n

\u2192 Rieckmann P., Heidenreich F., Sailer M., Zettl U.K., Zessack N., Hartung H.P., Gold R. Treatment de-escalation after mitoxantrone therapy: results of a phase IV, multicentre, open-label, randomized study of subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis. Ther Adv Neurol Disord; 5(1):3-12, 2012.<\/p>\n

\u2192 Rost M. Design und Auswertung einer Medizinproduktstudie \u2013 nur die Variation einer Arzneimittelstudie? DZKF 3\/4 \u2013 2012.<\/p>\n<\/div>

2011<\/h2><\/span>
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\u2192 Bidlingmaier C., Kurnik K., Escuriola-Ettingshausen C., Jager R., Klamroth R., Male C., Marosi A., Nemes L., von Stackelberg A., Kreuz W. Immune tolerance induction with a factor VIII concentrate containing con Willebrand factor (Haemoctin SDH\u00ae) in 14 patients with severe haemophilia A. Haemophilia; 1-4, 2011.<\/p>\n

\u2192 Eisenbraun J., Scheer R., Kroz M, Schad F., Huber R. Quality of life in breast cancer patients during chemotherapy and concurrenct therapy with a mistletoe extract. Phytomedicine; 18:151-157, 2011.<\/p>\n

\u2192 Espinola-Klein C., Weisser G., Jagodzinski A., Savvidis S., Warnholtz A., Ostad M-A., Gori T., Munzel T. b-Blockers in Patients With Intermittent Claudication and Arterial Hypertension: Results From the Nebivolol or Metoprolol in Arterial Occlusive Disease Trial. Hypertension; 58:148-154, 2011.<\/p>\n

\u2192 Hahn A., Novotny M., Shotekov P.M., Cirek Z., Bognar-Steinberg I., Baumann W. Comparison of Cinnarazine\/Dimenhydrinate Fixed Combination with the Respective Monotherapies for Vertigo of Various Origins. Clin Drug Investig; 31 (6): 371-383, 2011.<\/p>\n

\u2192 Hefter H., Kupsch A., Mungersdorf M., Paus S., Stenner A., Jost W., on behalf of the Dysport Cervical Dystonia Study Group. A botulinum toxin A treatment algorithm for de novo mangement of torticollis and laterocollis. BMJ Open; 1:e000196, doi:10.1136\/bmjopen-2011-000196, 2011.<\/p>\n

\u2192 Herzog T., Lemmers H.P., Arlt G., Raakow R., Weimann A., Pascher A., Knoefel W. T., Hesse U., Scheithe K., Groll S., Uhl W. Treatment of postoperative ileus with choline citrate-results of a prospective, randomised, placebo-controlled, double-blind multicentre trial. Int J Colorectal Dis; 26:645-652, 2011.<\/p>\n

\u2192 Kleinert S., Tony H.P., Krause A., Feuchtenberger M., Wassenberg S., Richter C., Rother E., Spieler W., Gnann H., Wittig B.M. Impact of patient and disease characteristics on therapuetic success during adalimumab treatment of patients with rheumatoid arthritis: data from a German noninterventional observational study. Rheumatology international; 32(9):2759-67, 2011.<\/p>\n

\u2192 Laux G. und die VIVALDI-Studiengruppe. Antidepressive Therapie mit Agomelatin in der Facharztpraxis – Ergebnisse der VIVALDI-Studie. Psychopharmakotherapie; 18: 18-26, 2011.<\/p>\n

\u2192 Limberg R., F\u00fchrer K. Einfluss sozio\u00f6konomischer Faktoren auf Insulinverordnung und Dauer der Pen-Schulung. In: “Monitor Versorgungsforschung” (MVF); 03: 34-37, 2001.<\/p>\n<\/div>

2010<\/h2><\/span>
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\u2192 Bayas A., Japp G., Fulda U., Kallmann B.A. Injektionshilfen in der Basistherapie der Multiplen Sklerose. Erhebung bei Neurologen, MS-Betreuern und Patienten. Nervenheilkunde; 1-2: 57-62, 2010.<\/p>\n

\u2192 Koester R., Kaehler J., Ebelt H., Soeffker G., Werden K., Meinertz T. Ivabradine in combination with beta-blocker therapy for the treatment of stable angina pectoris in every day clinical practice. Clin Res Cardiol; 2010.<\/p>\n

\u2192 Laux G., Steinmann C. The antidepressant efficacy of agomelatine in daily practice: Interim-analysis of non-interventional study VIVALDI. Poster presentation, 2010 XXVII CINP CONGRESS, Hong Kong, China, June 6\u201310, 2010.<\/p>\n

\u2192 Recker K. Fortgeschrittenes Prostatakarzinom. Anwendungsbeobachtung: wirksames und vertr\u00e4gliches Hormon-Implantat. Der Urologe; 49, 2010 (Beilage).<\/p>\n

\u2192 Renieri G., Fuhrer K., Scheithe K., Lorenz K., Pfeiffer N., Thieme H. Efficacy and Tolerability of Preservative-Free Eye Drops Containing a Fixed Combination of Dorzolamide and Timolol in Glaucoma Patients. Journal of Ocular Pharmacology and Therapeutics; 26 (6): 596-603, 2010.<\/p>\n

\u2192 Richter J., Rudwaleit M., Scheithe K., Sieper J., Schneider M. Rheumar\u00fcckenchek: Entwicklung und Evaluation einer deutschsprachigen Screening Instrumentes f\u00fcr Spondylarthritiden. Z Rheumatol; 69 Suppl 1: 1-92, 2010.<\/p>\n

\u2192 Richter J., Rudwaleit M., Scheithe K., Sieper J., Schneider M. Rheumabackcheck: Development and evaluation of a German language screening instrument for spondyloarthritides. Ann Rheum Dis; 69(Suppl3):650, 2010.<\/p>\n

\u2192 Werner A., Stahn A., Schlabs T., Noack T., Koralewski H.E., Scheithe K., Jahn E., Gunga, H.C. Effects of Nebivolol (Nebilet\u00a9) on Cardiovascular and Thermoregulatory Functions under Real and Simulated Microgravity Conditions. Oral presentation, Session 1b: Cardiovascular Research II (05) at Life in Space for Life on Earth, 13-18 June 2010, Trieste, Italy, ESA.<\/p>\n<\/div>

2009<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Hefter H., Benecke R., Erbguth F., Jost W., Reichel G. Treatment of heterogeneous subtypes of cervical dystonia with Botulinum Toxin A (500 Units Dysport\u00ae) \u2013 first results of a multicentre open study. Poster presentation, 13th International Congress of Parkinson\u2019s Disease and Movement Disorders, Paris, France, June 7\u201311, 2009.<\/p>\n

\u2192 Herzog T., Lemmers H.P., Arlt G., Raakow R., Weimann A., Pascher A., Knoefel W. T., Hesse U., Scheithe K., Groll S., Uhl W. Cholincitrat for the treatment of postoperative ileus after colorectal surgery. Results of a multicentre trial. Abstract, Colorectal Congress St. Gallen, 2nd – 4th December 2009.<\/p>\n

\u2192 K\u00f6ster R., Kaehler J., Meinertz T. for the REDUCTION Study Group. Treatment of stable angina pectoris by ivabradine in every day practice: The REDUCTION Study. Am Heart J; 158: e51-e57, 2009.<\/p>\n<\/div>

2008<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Erb C., Gast U., Schremmer D. German register for glaucoma with dry eye. I. Basic outcome with respect to dry eye. Graefes Arch Clin Ophthalmol; 246: 1593-1601, 2008.<\/p>\n

\u2192 Hefter H., Benecke R., Erbguth F., Jost W., Reichel G. Treatment of heterogeneous forms of cervical
\ndystonia with Botulinum Toxin A (500 Units Dysport\u00ae) – first aspects of a multicentre open study -. Poster presentation, Toxins 2008, 12-15 June, Baveno, Lago Maggiore, Italy.<\/p>\n

\u2192 Ludwig M., Zielinski T., Schremmer D., Stumpe K.O. Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque. Cardiovascular Ultrasound; 6:42, 2008.<\/p>\n<\/div>

2007<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Angstwurm M.W., Engelmann L., Zimmermann T., Lehmann C., Spes C., Abel P., Strau\u00df R., Meier-Hellmann A., Insel R., Radke J., Schuttler J., Gartner R. Selenium in Intensive Care (SIC) study: Results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med; 35: 1-9, 2007.<\/p>\n

\u2192 Deuschl G., Vaitkus A., Fox G.C., Roscher T., Schremmer D., Gordin A. Efficacy and Tolerability of Entacapone Versus Cabergoline in Parkinsonian Patients Suffering from Wearing-Off. Movement Disorders; Vol. 22, No. 11, 1550-1555, 2007.<\/p>\n

\u2192 Engels A., Schr\u00f6er U., Schremmer D. B-Vitamine steigern die Vitalit\u00e4t. MMW Fortschritte der Medizin Nr.49-50 \/ 2007 (149. Jg).<\/p>\n

\u2192 Parhofer K.G., Munzel F., Krekler M. Effect of the angiotensin receptor blocker irbesartan on metabolic parameters in clinical practice: the DO-IT prospective observational study. Cardiovascular Diabetology; 6:36, 2007.<\/p>\n

\u2192 Schmidt A.C., Graf C., Broxius K., Scholze J. Blood Pressure-Lowering Effect of Nebivolol in Hypertensive Patients with Type 2 Diabetes Mellitus: The YESTONO Study. Clin Drug Invest; 27: 841-849, 2007.<\/p>\n

\u2192 Stumpe K.O., Agabiti-Rosei E., Zielinski T., Schremmer D., Scholze J., Laeis P., Schwandt P., Ludwig
\nM. Carotid intima-media thickness and plaque volume changes following 2-year angiotensin II-receptor blockade. The Multicentre Olmesartan atherosclerosis Regression Evaluation (MORE) study. Therapeutic Advances in Cardiovascular Disease; 1, 97, 2007.<\/p>\n<\/div>

2006<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Huber R.M., Reck M., Gosse H., von Pawel J., Mezger J., Saal J.G., Kleinschmidt R., Steppert C., Steppling H. Efficacy of a toxicity-adjusted topotecan therapy in recurrent small cell lung cancer. Eur Respir J; 27, 1183-1189, 2006.<\/p>\n

\u2192 Rzany B., Ascher B., Fratila A., Monheit G.D., Talarico S., Sterry W. Efficacy and Safety of 3- and 5-Injection Patterns (30 and 50 U) of Botulinum Toxin A (Dysport) for the Treatment of Wrinkles in the Glabella and the Central Forehead Region. Arch Dermatol; Vol 142: 320 – 326, 2006.<\/p>\n

\u2192 Schermund A., Achenbach S., Budde T., Buziashvili Y., Forster A., Guy F., Henein M., Kerkhoff G., Knollmann F., Kukharchuk V., Lahiri A., Leischik R., Moshage W., Scartl M., Siffert W., Steinhagen-Thiessen E., Sinitsyn V., Vogt A., Wiedeking B., Erbel R. Effect of Intensive Versus Standard Lipid-Lowering Treatment With Atorvastatin on the Progression of Calcified Coronary Atherosclerosis Over 12 Months. A Multicenter, Randomized, Double-Blind Trail. Circulation; 113:427-437, 2006.<\/p>\n<\/div>

2004<\/h2><\/span>
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\u2192 Ismail C., Schremmer D., Steindl H. Tonsipret is safe and effective in children suffering from uncomplicated respiratory infections. Results of the first non-interventional study. Congress Phytopharmaka and Phytotherapie 2004.<\/p>\n

\u2192 Muhlhofer A., Mrosek S., Schlegel B., Trommer W., Rozario F., Bohles H., Schremmer D., Zoller WG., Biesalki HK. High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers. European Journal of Clinical Nutrition; 58: 1151-1158, 2004.<\/p>\n

\u2192 Reinartz S., Kohler S., Schlebusch H., Krista K., Giffels P., Renke K., Huober J., Mobus V., Kreienberg R., DuBois A., Sabbatini P., Wagner U. Vaccination of Patients with Advanced Ovarian Carcinoma with the Anti-Idiotype ACA125: Immunological Response and Survival (Phase Ib\/II). Clin Cancer Res; 10: 1580-1587, 2004.<\/p>\n<\/div>

2003<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Brockow K., Hautmann C., Fotisch K., Rakoski J., Borelli S., Vieths S., Ring J. Orange-induced skin lesions in patients with atopic eczema: evidence for a non-IgE-mediated mechanism. Acta Derm Venereol; 83(1): 44-48, 2003.<\/p>\n

\u2192 Hautmann C., Pfr\u00fcnder D. Sulbactam in Kombination mit \u00df-Laktam-Antibiotika. Medizin Forum aktuell Nr. 300; Beilage in der Zeitschrift Medizinische Klinik 9, 2003.<\/p>\n<\/div>

2002<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Werner G., M\u00e4rz R.E., Schremmer D. Assalix for chronic low back pain and arthralgia: Interim analysis of a post-marketing surveillance study. Focus on Alternative and Complementary Therapies; 7: 115, 2002.<\/p>\n<\/div>

2001<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Heckmann M., Ceballos-Baumann A.O., Plewig G. Botulinum Toxin A for Axillary Hyperhidrosis (Excessive Sweating). N Engl J Med; Vol. 344, No. 7, February 15: 488-492, 2001.<\/p>\n<\/div>

2000<\/h2><\/span>
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\u2192 Hautmann C., Scheithe K. Fluidextrakt aus Agropyron repens bei Harnwegsinfektionen oder Reizblase. Zeitschrift f\u00fcr Phytotherapie; 21: 252-255, 2000.<\/p>\n

\u2192 Hautmann C., Schremmer D. Wirksamkeit und Vertr\u00e4glichkeit von Medivitan\u00ae N. Ergebnisse einer multizentrischen Anwendungsbeobachtung. VitaMinSpur; 15: 125-129, 2000.<\/p>\n<\/div>

1999<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Hautmann C., Gratzl S., Simon D., Sigusch B., Nestle F.O., Simon H.-U. Kutane Zytokin-produzierende T-Lymphomzellen assoziiert mit Atopie und Hypereosinophilie. Hautarzt; 10-99; 50: 743-747, 1999.<\/p>\n

\u2192 M\u00fcller B. Behandlung von Kindern mit akuten Atemwegserkrankungen, Wirksamkeit und Vertr\u00e4glichkeit von Efeubl\u00e4ttertrockenextrakt. \u00c4rztliche Praxis Extra; Ausgabe 2, Februar 1999.<\/p>\n

\u2192 Schremmer D., Bognar-Steinberg I., Baumann W., Pytel J. Efficacy and Tolerability of a Fixed Combination of Cinnarizine and Dimenhydrinate in Treatment of Vertigo. Analysis of Data from Five Randomised, Double-Blind Clinical Studies. Clin Drug Invest; 18 (5): 355-368, 1999.<\/p>\n

\u2192 Schweizer J., Hautmann C. Comparison of Two Dosages of Ginkgo Biloba Extract EGb 761 in Patients with Peripheral Arterial Occlusive Disease Fontaine\u2019s Stage IIb: A randomised, double-blind, multicentric clinical trial. Arzneimittel Forschung Drug Research; 49 (II): 900-904, 1999.<\/p>\n<\/div>

1998<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Finelli A., Limberg R., Scheithe K. Mistel-Lektin bei Patienten mit Tumorerkrankungen. Diagnostik und Therapie im Bild; Sonderheft 1, 1998.<\/p>\n

\u2192 Hautmann C., Disch R., Borelli S., Simon D. Bronchospasmus nach systemischer Gabe von Methylprednisolon-21-hydrogensuccinat bei oraler Toleranz von Methylprednisolon. Allergo Journal; Vol 7: 203-206, 1998.<\/p>\n

\u2192 J\u00f6rg J. Therapie des Morbus Parkinson mit \u03b1-Dihydroergocryptin in der neurologischen Praxis. Akt. Neurologie; 25: 198-201, 1998.<\/p>\n

\u2192 Sarnow E., Pfr\u00fcnder D. Azithromycin bei Patienten mit Atemwegserkrankungen. Wiener klinische Wochenschrift; Springer-Verlag, 1998.<\/p>\n

\u2192 Steinhoff B. J. Antiepileptic Pharmacotherapy with Sustained Release Sodium Valproate, Post Marketing Surveillance of Orfiril\u00ae 300 retard. Ces a Slov. Neurol. Neurochir., 61\/94, No. 6: 291-295, 1998.<\/p>\n<\/div>

1997<\/h2><\/span>
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\u2192 Benos J., Braun R., Finelli A., Schremmer D. MEDIVITAN\u00aeN (Vitamin B6, B12, Fols\u00e4ure) bei Alkoholkranken in der Rehabilitation. Sucht; 43 (6): 430-435, 1997.<\/p>\n

\u2192 Hoppe J.E. Treatment of oropharyngeal candidiasis in immunocompetent infants: a randomized multicenter study of miconazole gel vs. nystatin suspension. Pediatric Infectious Disease Journal; 16: 288-293, 1997.<\/p>\n

\u2192 Limberg R. Die Mistel-Lektin-Therapie in der Praxis, Behandlungserfolg mit Lektinol\u00ae. Madaus Sonderheft, August 1997.<\/p>\n<\/div>

1996<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Diener H.C., Oldenburg J., Schremmer D. Behandlung akuter Migr\u00e4neattacken mit Sumatriptan s.c. Z Allg Med 1996; 72: 700-706, 1996.<\/p>\n

\u2192 Hippe S.K. Akute Migr\u00e4ne, Risikolos schnell schmerzfrei. Therapiewoche; 5: 296-297, 1996.<\/p>\n

\u2192 Meyer-Wegener J., Schmidramsl H., Reuter H.D., Schremmer D., Karl J. Neue Wege in der Herz-Kreislauf-Therapie. Gesundes Leben; 1\/96: 28-29, 1996.<\/p>\n

\u2192 Schremmer D. Kombination pflanzlicher Wirkstoffe senkt offenbar Blutdruck und Gewicht. \u00c4rztezeitung; 55, 1996.<\/p>\n<\/div>

1994<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Hasselkus W. Vorteile der niedrigdosierten Biguanid-Therapie. MWI; Nr. 74, Montag 25. April 1994.<\/p>\n

\u2192 Middeke M., Krone W. Effects of Perindopril on Serum Lipids in Hypertensive Patients with Hyperlipidemia. Journal of Cardiovascular Pharmacology; 23: 629-631, 1994.<\/p>\n

\u2192 Overlack A., Adamczak M.D., Bachmann W., Bonner G., Bretzel R.G., Derichs R., Krone W., Lederle R.M., Reimann H.J., Zschiederich H., Stumpe K.O. ACE-Inhibition with perindopril in essential hypertensive patients with concomitant diseases. The American Journal of Medicine; Volume 97: 126-134, 1994.<\/p>\n<\/div>

1993<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 B\u00f6nner G., Lederle R.M., Scholze J., Stumpe K.O. Therapeutic safety of perindopril in the treatment of mild hypertension. Arzneimittelforschung; 43 (8): 852-855, 1993.<\/p>\n

\u2192 Soyka M., Ablus M., Finelli A., Hofstetter S., Immler B., Kathmann N., Holzbach R., Sand P. Prevalence of alcohol and drug abuse in schizophrenic inpatients. Eur Arch Psychiatry Clin Neurosci; 242: 362-372, 1993.<\/p>\n

\u2192 Stumpe K.O., Overlack A. A New Trial of the Efficacy, Tolerability and Safety of Angiotensin-Converting Enzyme Inhibition in Mild Systemic Hypertension with Concomitant Diseases and Therapies. Am J Cardiol; Volume 71: 32E – 37E, 1993.<\/p>\n<\/div>

1992<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Papp R., Lehrl S., Frank S., Burger A., Willemsen A., Woelk H., Burkard G., Hippe S.K. Vitalit\u00e4t und Vitalit\u00e4tsverlust – Begriffe und Messm\u00f6glichkeiten. extracta psychiatrica; Jg 6, Heft 4: 37-47, 1992.<\/p>\n

\u2192 Stumpe K.O. Portrait eines Pharmakons: Celiprolol. Hochdrucktherapie: Blutdrucksenkung und was noch? Der Kassenarzt; 5: 53-56, 1992.<\/p>\n

\u2192 Stumpe K.O., Overlack A. Angiotensin-Converting Enzyme Inhibition in Mild Hypertension with Concomitant Diseases and Therapies: An Efficacy, Safety and Compatibility Study of Novel Design, the Perindopril Therapeutic Safety Study. Am J Medicine; Volume 92 (suppl 4B) 98S, 1992.<\/p>\n<\/div>

1991<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Frank S., Lehrl S., Papp R., Woelk H., Benos J., Berthermann O., B\u00f6ther K., Burkard G., Hippe S.K., Schr\u00f6der U. Zum Einfluss von B- und C-Vitaminen auf Lebensqualit\u00e4t und Vitalit\u00e4t. extracta psychiatrica; Jg. 5, Heft 10: 40-47, 1991.<\/p>\n

\u2192 Gr\u00e4\u00dfel E., Benos J., B\u00f6ther K., Burkard G., Hippe S.K., Reimann H.J. Verlust- und \u00dcberforderungssyndrome in der modernen Gesellschaft aus \u00e4rztlicher und medizinpsychologischer Sicht. medwelt; 42: 356-359, 1991.<\/p>\n<\/div>

1990<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Mai B. Dyspepsie – eine Herausforderung an \u00e4rztliches Denken und Handeln. Interdisziplin\u00e4rer Workshop, Budapest. International Society of Internal Medicine; 4, Sonderheft, 1990.<\/p>\n<\/div>

1988<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Maiwald L., Ewers H.R., Rapp W., Klapdor R., Brilmayer H. Enzynorm\u00aeforte – Funktionelle Bedeutung und klinische Wirksamkeit. Workshop unter dem Vorsitz von Prof. Dr. med. M. Classen im Mai 1986. Periodica Medica; Einhorn-Presse Verlag, 1988.<\/p>\n<\/div>

1987<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Hippe S.K. Psychodiagnostik, Ein Arzt-Service-Programm stellt sich vor. Pharma-Marketing-Journal; 4\/87: 143-144, 1987.<\/p>\n

\u2192 Schmidt W. Zur Therapie der chronischen Bronchitis, randomisierte Doppelblindstudie mit Asthmakhell\u00ae. Therapiewoche; 37: 2803-2809, 1987.<\/p>\n<\/div>

1986<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Becker W. Funktionelle Schlafst\u00f6rungen. Besseres Schlafverhalten und bessere Schlafqualit\u00e4t mit dem Phytopharmakon Phytonoxon\u00ae. Therapiewoche; 36: 3830-3836, 1986.<\/p>\n

\u2192 Schulte R.M., Burkard G., Hippe S.K., Kuntz H.D. Die Entwicklung eines Psychodiagnostikums f\u00fcr Gastritis-Patienten. Psycho; 12: 950-959, 1986.<\/p>\n<\/div>

1985<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Daunderer W. Schonende Behandlung der Altershypertonie. Multizentrische Praxisstudie mit Ergodesit spezial. Fortschritte der Medizin; 103 Jg., Nr. 25: 680-682, 1985.<\/p>\n

\u2192 Daunderer W., Daunderer M. Altershypertonie und Multimorbidit\u00e4t. Hochdruck, 5: 31-34, 1985.<\/p>\n

\u2192 Weede W. Chronische Bronchitis, vertr\u00e4gliche und nebenwirkungsfreie Therapie mit einem Phytopharmakon. Therapiewoche; 35: 5750-5754, 1985.<\/p>\n<\/div>

1984<\/h2><\/span>
<\/div><\/div><\/div>

\u2192 Franek A. Phytodolor\u00ae – Ein neuer Weg in der Rheumatherapie. Rheuma Schmerz & Entz\u00fcndung; PMI-Verlag, 4, Sonderdruck, 1984.<\/p>\n

\u2192 Heidland A. Bluthochdruck im h\u00f6heren Lebensalter, Therapeutische \u00dcberlegungen. Hochdruck; 5: 28-32, 1984.<\/p>\n

\u2192 Schnelle K. Bedeutung und H\u00e4ufigkeit von Altershochdruck mit zerebraler Insuffizienz in der t\u00e4glichen Praxis. Der Praktische Arzt; 26: 1762-1764, 1984.<\/p>\n<\/div>

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